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Project: In vivo characterization and validation of novel blood-brain barrier targets and their potential for brain delivery of biotherapeutics


The postdoctoral position will be working in the research group of Translational Pharmacokinetics and Pharmacodynamics (tPKPD; http://www.farmbio.uu.se/research/researchgroups/tPKPD/). The group takes a multidisciplinary approach to improve the understanding of fundamental and functional aspects of PKPD in health and disease, with special focus on drug delivery to the brain. Within this area, the group among other projects addresses translation of PK data from the preclinical to the clinical setting. This is important for optimizing the drug discovery processes and promoting efficient treatment of CNS diseases. We are interested in brain drug delivery in relation to transport processes of both small and large molecules across the CNS barriers including the blood-brain barrier (BBB).


The postdoctoral position will focus on in vivo characterization and validation of novel BBB targets and their potential for brain delivery of biotherapeutics using pharmacokinetic methods. The project is a part of the EU IMI2-RIA funded project IM2PACT - Investigating Mechanisms and Models Predictive of Accessibility of Therapeutics Into The Brain (http://im2pact.org/). IM2PACT is a consortium of 27 international partners from academia, industry, and small and medium enterprises, aims to tackle the unmet challenge of discovery and characterisation of blood-brain barrier targets and transport mechanisms for brain delivery of therapeutics to treat neurodegenerative and
metabolic diseases.


See details here: https://uu.varbi.com/en/what:job/jobID:340667/