Denali Therapeutics (South San Francisco, California) is dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to the biology of neurodegeneration and principles of translational medicine. We are currently seeking to recruit talented researchers at the Scientist level to join our BBB Pathway Biology group to help us explore BBB biology and mechanisms underlying the biodistribution of our BBB-crossing therapeutics for neurodegenerative disorders. These scientists would be joining a group with decades of experience in the CNS barriers field and would be well integrated into project teams working closely with team members having broad drug development expertise.

We are seeking independently motivated candidates with high energy, excellent oral and written communication skills, and a passion for translational science to investigate BBB platform biology in support of our large molecule neurodegenerative disease therapeutic programs. The focus of research will be identifying and performing key biological experiments that build upon our work targeting novel engineered proteins to the brain in multiple species and neurodegenerative disease models (Scearce-Levie et al. Nature Reviews Drug Discovery, 2020; Kariolis et al. Science Translational Medicine, 2020; Ullman et al. Science Translational Medicine, 2020).

Ideal candidates will have extensive experience with some combination of biochemical, cellular, in vivo, and imaging-based assays to evaluate BBB and CNS biology. Responsibilities will include leading and contributing to on-going BBB projects, working closely with external academic partners, other biotech companies and contract research organizations, and communicating experimental strategies and key results. Successful candidates should have a PhD in a related field and a record of high-level publications focused on cell biology/neurobiology. Additional post-doctoral training and/or industry experience is strongly preferred.

Interested candidates can apply via the following link:

For further information about the positions: Please contact either Dr. Joy Zuchero () or Dr. Robert Thorne ().