The laboratory of Associate Professor Scott Canfield at Indiana University School of Medicine – Terre Haute, is seeking a talented and highly motivated Postdoctoral Researcher to join a pioneering research project within the framework of our recently NIH funded Micro physiological Systems to Advance Precision Medicine for Alzheimer’s Disease and Related Dementias (MAP-AD). This innovative and multidisciplinary project aims to develop brain oganoids derived from human iPSCs- to study vascular dysfunction in Alzheimer’s disease and related dementias. Project Overview Leveraging newly developed brain organoid models, this project will: Utilize human iPSC lines from AD patients to develop multiple tiered brain organoid models. Investigate vascular dysfunction and neuroinflammation in three-dimensional cellular models, Utilize cutting-edge techniques including confocal microscopy, physiological and shear flow, and artificial intelligence systems to enable functional phenotyping of the MAP-AD models. Improve translational micro physiological systems models to improve AD outcomes.
Project Overview
Leveraging newly developed brain organoid models, this project will:
- Utilize human iPSC lines from AD patients to develop multiple tiered brain organoid models.
- Investigate vascular dysfunction and neuroinflammation in three-dimensional cellular models
- Utilize cutting-edge techniques including confocal microscopy, physiological and shear flow, and artificial intelligence systems to enable functional phenotyping of the MAP-AD models.
- Improve translational microphysiological systems models to improve AD outcomes.
To apply for the position please submit your application here: https://indiana.peopleadmin.com/postings/30477